东南大学医学院，病原生物学与免疫学系

东南大学附属两江医院

E-mail: rlei001@seu.edu.cn

雷瑞鹏，东南大学青年首席教授、博士/硕士生导师。2020年于佛罗里达国际大学获得生物化学博士学位， 2020年至2025年在伊利诺伊大学厄巴纳-香槟分校从事博士后研究工作，师从Dr.Nicholas C. Wu。2025年底入职东南大学医学院，病原生物学与免疫学系，并双聘于东南大学附属两江医院，担任检验科科研副主任。主要研究方向为病毒表面糖蛋白的进化和抗原性的鉴别。研究成果已发表SCI论文20余篇，主要研究成果以第一/共同第一作者发表在Immunity、Nature Communications、Cell Reports以及eLife等国际权威杂志上。

课题组现招收有意向的博士后、博士/硕士、及科研助理，请有意向的同学邮件联系。

代表性论文(*共一作)

1. Ruipeng Lei*, Wooseob Kim*, Huibin Lv*, Zongjun Mou*, Michael J. Scherm*, Aaron J. Schmitz, Jackson S. Turner, Timothy J.C. Tan, Yiquan Wang, Wenhao O. Ouyang, Weiwen Liang, Joel Rivera-Cardona, Chuyun Teo, Claire S. Graham, Christopher B. Brooke, Rachel M. Presti, Chris K.P. Mok, Florian Krammer, Xinghong Dai, Ali H. Ellebedy, Nicholas C. Wu. Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase. Immunity. 56, 2621-2634.e6 (2023)
2. Ruipeng Lei*, Weiwen Liang*, Wenhao O Ouyang*, Andrea Hernandez Garcia*, Chika Kikuchi, Shengyang Wang, Ryan McBride, Timothy JC Tan, Yuanxin Sun, Chunke Chen, Claire S Graham, Lucia A Rodriguez, Ivana R Shen, Danbi Choi, Roberto Bruzzone, James C Paulson, Satish K Nair, Chris KP Mok, Nicholas C Wu. Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin. Nature Communications.15, 5175 (2024)
3. Ruipeng Lei*, Enya Qing*, Abby Odle, Meng Yuan, Timothy J.C. Tan, Natalie So, Wenhao O. Ouyang, Ian A. Wilson, Tom Gallagher, Stanley Perlman, Nicholas C. Wu, Lok-Yin Roy Wong. Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning. Nature Communications.15, 4056 (2024)
4. Ruipeng Lei, Andrea Hernandez Garcia, Timothy J.C. Tan, Qi Wen Teo, Yiquan Wang, Xiwen Zhang, Shitong Luo, Satish K. Nair, Jian Peng, Nicholas C. Wu. Mutational fitness landscape of human influenza H3N2 neuraminidase. Cell Reports. 42:111951 (2023)
5. Ruipeng Lei,Timothy J.C. Tan, Andrea Hernandez Garcia, Yiquan Wang, Meghan Diefenbacher, Chuyun Teo, Gopika Gopan, Zahra Tavakoli Dargani, Qi Wen Teo, Claire S. Graham, Christopher B. Brooke, Satish K. Nair, Nicholas C. Wu. Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase. Nature Communications 13:6443 (2022)
6. Yiquan Wang*, Ruipeng Lei*, Armita Nourmohammad, Nicholas C. Wu. Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing. eLife10:e72516 (2021)

专利

Yuan Liu, Yanhao Lai, Ruipeng Lei. High throughput measurement of DNA base lesion repair capacity. U.S. Patent number: 9809843.