{"id":7119,"date":"2026-05-06T13:35:53","date_gmt":"2026-05-06T05:35:53","guid":{"rendered":"https:\/\/wp.meddatas.com\/?p=7119"},"modified":"2026-05-06T13:35:53","modified_gmt":"2026-05-06T05:35:53","slug":"%e9%9b%b7%e7%91%9e%e9%b9%8f","status":"publish","type":"post","link":"https:\/\/wp.meddatas.com\/?p=7119","title":{"rendered":"\u96f7\u745e\u9e4f"},"content":{"rendered":"

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\u4e1c\u5357\u5927\u5b66\u533b\u5b66\u9662\uff0c\u75c5\u539f\u751f\u7269\u5b66\u4e0e\u514d\u75ab\u5b66\u7cfb<\/p>\n

\u4e1c\u5357\u5927\u5b66\u9644\u5c5e\u4e24\u6c5f\u533b\u9662<\/p>\n

E-mail: rlei001@seu.edu.cn<\/p>\n

\u96f7\u745e\u9e4f\uff0c\u4e1c\u5357\u5927\u5b66\u9752\u5e74\u9996\u5e2d\u6559\u6388\u3001\u535a\u58eb\/\u7855\u58eb\u751f\u5bfc\u5e08\u30022020\u5e74\u4e8e\u4f5b\u7f57\u91cc\u8fbe\u56fd\u9645\u5927\u5b66\u83b7\u5f97\u751f\u7269\u5316\u5b66\u535a\u58eb\u5b66\u4f4d\uff0c 2020\u5e74\u81f32025\u5e74\u5728\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u5384\u5df4\u7eb3-\u9999\u69df\u5206\u6821\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\u5de5\u4f5c\uff0c\u5e08\u4eceDr.Nicholas C. Wu\u30022025\u5e74\u5e95\u5165\u804c\u4e1c\u5357\u5927\u5b66\u533b\u5b66\u9662\uff0c\u75c5\u539f\u751f\u7269\u5b66\u4e0e\u514d\u75ab\u5b66\u7cfb\uff0c\u5e76\u53cc\u8058\u4e8e\u4e1c\u5357\u5927\u5b66\u9644\u5c5e\u4e24\u6c5f\u533b\u9662\uff0c\u62c5\u4efb\u68c0\u9a8c\u79d1\u79d1\u7814\u526f\u4e3b\u4efb\u3002\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u4e3a\u75c5\u6bd2\u8868\u9762\u7cd6\u86cb\u767d\u7684\u8fdb\u5316\u548c\u6297\u539f\u6027\u7684\u9274\u522b\u3002\u7814\u7a76\u6210\u679c\u5df2\u53d1\u8868SCI\u8bba\u658720\u4f59\u7bc7\uff0c\u4e3b\u8981\u7814\u7a76\u6210\u679c\u4ee5\u7b2c\u4e00\/\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u53d1\u8868\u5728Immunity\u3001Nature Communications\u3001Cell Reports\u4ee5\u53caeLife\u7b49\u56fd\u9645\u6743\u5a01\u6742\u5fd7\u4e0a\u3002<\/p>\n

\u8bfe\u9898\u7ec4\u73b0\u62db\u6536\u6709\u610f\u5411\u7684\u535a\u58eb\u540e\u3001\u535a\u58eb\/\u7855\u58eb\u3001\u53ca\u79d1\u7814\u52a9\u7406\uff0c\u8bf7\u6709\u610f\u5411\u7684\u540c\u5b66\u90ae\u4ef6\u8054\u7cfb\u3002<\/p>\n

\u4ee3\u8868\u6027\u8bba\u6587<\/b><\/strong>(*\u5171\u4e00\u4f5c)<\/h6>\n
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  1. <\/b>Ruipeng Lei*<\/b><\/u><\/strong>, Wooseob Kim*, Huibin Lv*, Zongjun Mou*, Michael J. Scherm*, Aaron J. Schmitz, Jackson S. Turner, Timothy J.C. Tan, Yiquan Wang, Wenhao O. Ouyang, Weiwen Liang, Joel Rivera-Cardona, Chuyun Teo, Claire S. Graham, Christopher B. Brooke, Rachel M. Presti, Chris K.P. Mok, Florian Krammer, Xinghong Dai, Ali H. Ellebedy, Nicholas C. Wu. Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase. Immunity<\/i><\/em>. 56, 2621-2634.e6 (2023)<\/li>\n
  2. <\/b>Ruipeng Lei*<\/b><\/u><\/strong>, Weiwen Liang*, Wenhao O Ouyang*, Andrea Hernandez Garcia*, Chika Kikuchi, Shengyang Wang, Ryan McBride, Timothy JC Tan, Yuanxin Sun, Chunke Chen, Claire S Graham, Lucia A Rodriguez, Ivana R Shen, Danbi Choi, Roberto Bruzzone, James C Paulson, Satish K Nair, Chris KP Mok, Nicholas C Wu. Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin. Nature Communications.<\/i><\/em>15<\/b><\/strong>, 5175 (2024)<\/li>\n
  3. <\/b>Ruipeng Lei*<\/b><\/u><\/strong>, Enya Qing*, Abby Odle, Meng Yuan, Timothy J.C. Tan, Natalie So, Wenhao O. Ouyang, Ian A. Wilson, Tom Gallagher, Stanley Perlman, Nicholas C. Wu, Lok-Yin Roy Wong. Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning. Nature Communications.<\/i><\/em>15<\/b><\/strong>, 4056 (2024)<\/li>\n
  4. <\/b>Ruipeng Lei<\/b><\/u><\/strong>, Andrea Hernandez Garcia, Timothy J.C. Tan, Qi Wen Teo, Yiquan Wang, Xiwen Zhang, Shitong Luo, Satish K. Nair, Jian Peng, Nicholas C. Wu. Mutational fitness landscape of human influenza H3N2 neuraminidase. Cell Reports<\/i><\/em>. 42:111951 (2023)<\/li>\n
  5. <\/b>Ruipeng Lei,<\/b><\/u><\/strong>Timothy J.C. Tan, Andrea Hernandez Garcia, Yiquan Wang, Meghan Diefenbacher, Chuyun Teo, Gopika Gopan, Zahra Tavakoli Dargani, Qi Wen Teo, Claire S. Graham, Christopher B. Brooke, Satish K. Nair, Nicholas C. Wu. Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase. Nature Communications<\/i><\/em>\u00a013:6443 (2022)<\/li>\n
  6. Yiquan Wang*, Ruipeng Lei*<\/b><\/u><\/strong>, Armita Nourmohammad, Nicholas C. Wu. Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing. eLife<\/i><\/em>10:e72516 (2021)<\/li>\n<\/ol>\n
    \u4e13\u5229<\/b><\/strong><\/h6>\n
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    Yuan Liu, Yanhao Lai, Ruipeng Lei<\/u><\/strong>. High throughput measurement of DNA base lesion repair capacity. U.S. Patent number: 9809843.<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u4e1c\u5357\u5927\u5b66\u533b\u5b66\u9662\uff0c\u75c5\u539f\u751f\u7269\u5b66\u4e0e\u514d\u75ab\u5b66\u7cfb \u4e1c\u5357\u5927\u5b66\u9644\u5c5e\u4e24\u6c5f\u533b\u9662 E-mail: rlei001@seu.edu.c …<\/p>\n

    \u96f7\u745e\u9e4f<\/span> \u67e5\u770b\u5168\u6587 »<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[83],"tags":[],"_links":{"self":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts\/7119"}],"collection":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7119"}],"version-history":[{"count":1,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts\/7119\/revisions"}],"predecessor-version":[{"id":7121,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts\/7119\/revisions\/7121"}],"wp:attachment":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}