{"id":6036,"date":"2024-04-26T11:29:08","date_gmt":"2024-04-26T03:29:08","guid":{"rendered":"https:\/\/wp.meddatas.com\/?p=6036"},"modified":"2024-04-26T11:29:08","modified_gmt":"2024-04-26T03:29:08","slug":"%e4%b8%9c%e5%8d%97%e5%a4%a7%e5%ad%a6%e5%88%98%e6%b6%9b%e6%95%99%e6%8e%88%e8%af%be%e9%a2%98%e7%bb%84%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95%e5%9c%a8%e5%91%bc%e5%90%b8%e9%a2%86%e5%9f%9f%e9%a1%b6%e5%b0%96","status":"publish","type":"post","link":"https:\/\/wp.meddatas.com\/?p=6036","title":{"rendered":"\u4e1c\u5357\u5927\u5b66\u5218\u6d9b\u6559\u6388\u8bfe\u9898\u7ec4\u6700\u65b0\u8fdb\u5c55\u5728\u547c\u5438\u9886\u57df\u9876\u5c16\u6742\u5fd7European Respiratory Journal\u53d1\u8868"},"content":{"rendered":"<p><img loading=\"lazy\" class=\"size-full wp-image-6037 aligncenter\" src=\"https:\/\/wp.meddatas.com\/wp-content\/uploads\/2024\/04\/e1964304-ac83-47d0-a34c-791589b80e78.png\" alt=\"\" width=\"1767\" height=\"609\" srcset=\"https:\/\/wp.meddatas.com\/wp-content\/uploads\/2024\/04\/e1964304-ac83-47d0-a34c-791589b80e78.png 1767w, https:\/\/wp.meddatas.com\/wp-content\/uploads\/2024\/04\/e1964304-ac83-47d0-a34c-791589b80e78-300x103.png 300w, https:\/\/wp.meddatas.com\/wp-content\/uploads\/2024\/04\/e1964304-ac83-47d0-a34c-791589b80e78-1024x353.png 1024w, https:\/\/wp.meddatas.com\/wp-content\/uploads\/2024\/04\/e1964304-ac83-47d0-a34c-791589b80e78-768x265.png 768w, https:\/\/wp.meddatas.com\/wp-content\/uploads\/2024\/04\/e1964304-ac83-47d0-a34c-791589b80e78-1536x529.png 1536w\" sizes=\"(max-width: 1767px) 100vw, 1767px\" \/><\/p>\n<p><span lang=\"zh-CN\">\u54ee\u5598\u4f5c\u4e3a\u4e00\u79cd\u6162\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u5728\u5168\u7403\u5c24\u5176\u662f\u53d1\u8fbe\u56fd\u5bb6\u4e2d\u7684\u53d1\u75c5\u7387\u6301\u7eed\u4e0a\u5347\uff0c\u4f1a\u5bf9\u4e2a\u4f53\u7684\u5065\u5eb7\u3001\u5de5\u4f5c\u80fd\u529b\u3001\u793e\u4ea4\u4e92\u52a8\u548c\u60c5\u611f\u5065\u5eb7\u9020\u6210\u4e25\u91cd\u8d1f\u9762\u5f71\u54cd\u3002\u5c3d\u7ba1\u6709\u6548\u7684\u6cbb\u7597\u548c\u7ba1\u7406\u80fd\u591f\u63a7\u5236\u54ee\u5598\u75c7\u72b6\uff0c\u4f46\u65e0\u6cd5\u88ab\u5b8c\u5168\u6cbb\u6108\u3002<\/span><\/p>\n<p><span lang=\"zh-CN\">\u708e\u75c7\u5c0f\u4f53\u662f\u4e00\u79cd\u591a\u86cb\u767d\u590d\u5408\u7269\uff0c\u5728\u5bbf\u4e3b\u7ec6\u80de\u53d7\u5230\u635f\u4f24\u6216\u611f\u67d3\u65f6\u80fd\u591f\u542f\u52a8\u514d\u75ab\u548c\u708e\u75c7\u53cd\u5e94\u3002<\/span><span lang=\"en-US\">Gasdermin<\/span><span lang=\"zh-CN\">\u86cb\u767d\u662f\u4e00\u7c7b\u5728\u708e\u75c7\u5c0f\u4f53\u6fc0\u6d3b\u8fc7\u7a0b\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u5bb6\u65cf\uff0c\u901a\u8fc7\u5f62\u6210\u5b54\u9053\uff0c\u5bfc\u81f4\u7ec6\u80de\u819c\u7684\u7834\u88c2\uff0c\u4ece\u800c\u5f15\u53d1\u708e\u75c7\u6027\u7ec6\u80de\u6b7b\u4ea1\u53ca\u708e\u75c7\u53cd\u5e94\u3002<\/span><span lang=\"en-US\">GSDMB<\/span><span lang=\"zh-CN\">\uff08<\/span><span lang=\"en-US\">Gasdermin B<\/span><span lang=\"zh-CN\">\uff09\u4f5c\u4e3a<\/span><span lang=\"en-US\">Gasdermin<\/span><span lang=\"zh-CN\">\u86cb\u767d\u5bb6\u65cf\u4e2d\u7684\u4e00\u5458\uff0c\u662f\u5df2\u77e5\u6700\u91cd\u8981\u7684\u54ee\u5598\u6613\u611f\u57fa\u56e0\u3002\u5927\u91cf<\/span><span lang=\"en-US\">GWAS<\/span><span lang=\"zh-CN\">\u5206\u6790\u6570\u636e\u8868\u660e<\/span><span lang=\"en-US\">GSDMB<\/span><span lang=\"zh-CN\">\u4e0e\u54ee\u5598\u7684\u53d1\u751f\u53d1\u5c55\u5bc6\u5207\u76f8\u5173\uff0c\u4f46\u673a\u5236\u4e0d\u6e05\u3002\u8be5\u5de5\u4f5c\u901a\u8fc7\u8ba1\u7b97\u751f\u7269\u5b66\u7684\u624b\u6bb5\uff0c\u5728\u4e24\u4e2a\u72ec\u7acb\u54ee\u5598\u961f\u5217\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6570\u636e\u4e2d\uff0c\u53d1\u73b0<\/span><span lang=\"en-US\">GSDMB\u00a0<\/span><span lang=\"zh-CN\">\u548c\u5e72\u6270\u7d20\u523a\u6fc0\u57fa\u56e0\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u6b63\u76f8\u5173\u6027\u3002\u7ed3\u5408\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\u53ca\u8868\u8fbe\u6570\u91cf\u6027\u72b6\u57fa\u56e0\u5ea7\u5206\u6790\uff0c\u53d1\u73b0\u4e86\u708e\u75c7\u5c0f\u4f53\u76f8\u5173\u86cb\u767d<\/span><span lang=\"en-US\">GSDMB<\/span><span lang=\"zh-CN\">\u5f15\u53d1\u54ee\u5598\u7684\u673a\u5236\uff1a\u5728\u643a\u5e26\u6709<\/span><span lang=\"en-US\">rs2305480 (G&gt;A)\u00a0<\/span><span lang=\"zh-CN\">\u548c<\/span><span lang=\"en-US\">rs2305479 (C&gt;T)<\/span><span lang=\"zh-CN\">\u7a81\u53d8\u7684\u54ee\u5598\u75c5\u4eba\u4e2d\uff0c<\/span><span lang=\"en-US\">GSDMB<\/span><span lang=\"zh-CN\">\u53ca\u5e72\u6270\u7d20\u523a\u6fc0\u57fa\u56e0\u7684\u8868\u8fbe\u5747\u5347\u9ad8\uff0c\u8bc1\u660e\u4e86<\/span><span lang=\"en-US\">GSDMB<\/span><span lang=\"zh-CN\">\u4f5c\u4e3a\u4e00\u4e2a\u65b0\u578b\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\uff0c\u901a\u8fc7\u4ecb\u5bfc\u547c\u5438\u9053\u75c5\u6bd2<\/span><span lang=\"en-US\">RNA<\/span><span lang=\"zh-CN\">\u7684\u8bc6\u522b\uff0c\u6fc0\u6d3b\u5e72\u6270\u7d20\u523a\u6fc0\u57fa\u56e0\u8868\u8fbe\u3001\u7c98\u6db2\u5206\u6ccc\u3001\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u7684\u6d78\u6da6\u53ca\u708e\u75c7\uff0c\u5bfc\u81f4\u54ee\u5598\u6076\u5316\u3002<\/span><\/p>\n<p>\u4e1c\u5357\u5927\u5b66\u533b\u5b66\u9662\/\u6c5f\u82cf\u7701\u91cd\u75c7\u533b\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4<span lang=\"zh-CN\">\u5218\u6d9b<\/span>\u6559\u6388<span lang=\"zh-CN\">\u4e3a\u8bba\u6587\u72ec\u7acb\u7b2c\u4e00\u4f5c\u8005\uff0c<\/span>\u7f8e\u56fd<span lang=\"zh-CN\">\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662<\/span><span lang=\"en-US\">Raby Benjamin<\/span><span lang=\"zh-CN\">\u6559\u6388\u3001\u5e03\u83b1\u6839\u5987\u5973\u533b\u9662<\/span><span lang=\"en-US\">Xiaobo Zhou<\/span><span lang=\"zh-CN\">\u6559\u6388\u4e3a\u8bba\u6587\u901a\u8baf\u4f5c\u8005\u3002\u54c8\u4f5b\u5927\u5b66\u516c\u5171\u536b\u751f\u5b66\u9662<\/span><span lang=\"en-US\">Jin-Ah Park<\/span><span lang=\"zh-CN\">\u6559\u6388\u8bfe\u9898\u7ec4\uff0c\u54c8\u4f5b\u533b\u5b66\u9662\u5e03\u83b1\u6839\u5987\u5973\u533b\u9662<\/span><span lang=\"en-US\">Mark A. Perrella<\/span><span lang=\"zh-CN\">\u6559\u6388\u8bfe\u9898\u7ec4\uff0c<\/span><span lang=\"en-US\">Bruce D. Levy<\/span><span lang=\"zh-CN\">\u6559\u6388\u8bfe\u9898\u7ec4\uff0c<\/span><span lang=\"en-US\">Scott T. Weiss<\/span><span lang=\"zh-CN\">\u6559\u6388\u8bfe\u9898\u7ec4\u4ee5\u53ca\u54c8\u4f5b\u533b\u5b66\u9662\u9ebb\u7701\u603b\u533b\u9662<\/span><span lang=\"en-US\">Hongmei Mou<\/span><span lang=\"zh-CN\">\u6559\u6388\u8bfe\u9898\u7ec4\u90fd\u7ed9\u4e88\u4e86\u6781\u5927\u7684\u652f\u6301\u548c\u5e2e\u52a9\u3002<\/span><\/p>\n<blockquote><p>\u8bba\u6587\u94fe\u63a5\uff1a<a href=\"https:\/\/erj.ersjournals.com\/content\/early\/2024\/01\/08\/13993003.01232-2023\">https:\/\/erj.ersjournals.com\/content\/early\/2024\/01\/08\/13993003.01232-2023<\/a><\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>\u54ee\u5598\u4f5c\u4e3a\u4e00\u79cd\u6162\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u5728\u5168\u7403\u5c24\u5176\u662f\u53d1\u8fbe\u56fd\u5bb6\u4e2d\u7684\u53d1\u75c5\u7387\u6301\u7eed\u4e0a\u5347\uff0c\u4f1a\u5bf9\u4e2a\u4f53\u7684\u5065\u5eb7\u3001\u5de5\u4f5c\u80fd\u529b\u3001\u793e\u4ea4\u4e92\u52a8\u548c\u60c5\u611f\u5065 &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/wp.meddatas.com\/?p=6036\"> <span class=\"screen-reader-text\">\u4e1c\u5357\u5927\u5b66\u5218\u6d9b\u6559\u6388\u8bfe\u9898\u7ec4\u6700\u65b0\u8fdb\u5c55\u5728\u547c\u5438\u9886\u57df\u9876\u5c16\u6742\u5fd7European Respiratory Journal\u53d1\u8868<\/span> \u67e5\u770b\u5168\u6587 &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":6037,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[59],"tags":[],"_links":{"self":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts\/6036"}],"collection":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6036"}],"version-history":[{"count":1,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts\/6036\/revisions"}],"predecessor-version":[{"id":6038,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts\/6036\/revisions\/6038"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/media\/6037"}],"wp:attachment":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}