{"id":5899,"date":"2023-02-10T17:16:52","date_gmt":"2023-02-10T09:16:52","guid":{"rendered":"https:\/\/wp.meddatas.com\/?p=5899"},"modified":"2023-02-10T17:35:28","modified_gmt":"2023-02-10T09:35:28","slug":"%e6%b1%9f%e8%8b%8f%e7%9c%81%e9%87%8d%e7%97%87%e5%8c%bb%e5%ad%a6%e9%87%8d%e7%82%b9%e5%ae%9e%e9%aa%8c%e5%ae%a4%e5%a7%9a%e7%ba%a2%e7%ba%a2%e5%9b%a2%e9%98%9f%e6%8f%ad%e7%a4%ba%e7%8e%af%e7%8a%b6rna","status":"publish","type":"post","link":"https:\/\/wp.meddatas.com\/?p=5899","title":{"rendered":"\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u59da\u7ea2\u7ea2\u56e2\u961f\u63ed\u793a\u73af\u72b6RNA\u4fc3\u8fdb\u7f3a\u8840\u6027\u5352\u4e2d\u540e\u8840\u7ba1\u4fee\u590d\u7684\u4f5c\u7528\u53ca\u5176\u5206\u5b50\u673a\u5236"},"content":{"rendered":"<p>2023\u5e741\u670830\u65e5\uff0c\u4e1c\u5357\u5927\u5b66\u533b\u5b66\u9662\u3001\u6c5f\u82cf\u7701\u91cd\u75c7\u533b\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u59da\u7ea2\u7ea2\u6559\u6388\u56e2\u961f\u5728\u56fd\u9645\u6743\u5a01\u5b66\u672f\u671f\u520a\u300aNature\u00a0Communications\u300b\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a\u201cFTO-dependent m<sup>6<\/sup>A modification of <em><i>Plpp3<\/i><\/em>\u00a0in circSCMH1-regulated vascular repair and functional recovery following stroke\u201d\u7684\u7814\u7a76\u8bba\u6587\u3002\u8be5\u7814\u7a76\u4ecb\u7ecd\u4e86\u73af\u72b6RNA\u6cbb\u7597\u7f3a\u8840\u6027\u5352\u4e2d\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\uff0c\u660e\u786e\u4e86\u73af\u72b6RNA-circSCMH1\u4fc3\u8fdb\u7f3a\u8840\u6027\u5352\u4e2d\u540e\u8840\u7ba1\u4fee\u590d\u7684\u4f5c\u7528\u53ca\u5176\u5206\u5b50\u673a\u5236\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-5900 aligncenter\" src=\"https:\/\/wp.meddatas.com\/wp-content\/uploads\/2023\/02\/\u56fe\u72471.png\" alt=\"\" width=\"1022\" height=\"782\" srcset=\"https:\/\/wp.meddatas.com\/wp-content\/uploads\/2023\/02\/\u56fe\u72471.png 1022w, https:\/\/wp.meddatas.com\/wp-content\/uploads\/2023\/02\/\u56fe\u72471-300x230.png 300w, https:\/\/wp.meddatas.com\/wp-content\/uploads\/2023\/02\/\u56fe\u72471-768x588.png 768w\" sizes=\"(max-width: 1022px) 100vw, 1022px\" \/><\/p>\n<p>\u7f3a\u8840\u6027\u5352\u4e2d\uff08Ischemic 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Vesicle\uff0cEV\uff09\u80fd\u591f\u6709\u6548\u4fc3\u8fdb\u7f3a\u8840\u6027\u5352\u4e2d\u6a21\u578b\u6052\u6cb3\u7315\u7334\u548c\u5c0f\u9f20\u8111\u4fee\u590d\uff0c\u4f46\u662f\uff0c\u5176\u5bf9\u8840\u7ba1\u4fee\u590d\u7684\u4f5c\u7528\u53ca\u5206\u5b50\u673a\u5236\u4ecd\u7136\u672a\u77e5\u3002<\/p>\n<p>\u7814\u7a76\u56e2\u961f\u9996\u5148\u53d1\u73b0\uff0cEV-circSCMH1\u80fd\u591f\u6709\u6548\u4fc3\u8fdb\u7f3a\u8840\u6027\u5352\u4e2d\u6a21\u578b\u5c0f\u9f20\u4e0e\u6052\u6cb3\u7315\u7334\u8111\u8840\u7ba1\u4fee\u590d\uff0c\u5e76\u4e14\u663e\u8457\u964d\u4f4e\u5352\u4e2d\u6a21\u578b\u5c0f\u9f20\u8111\u90e8<em><i>N<\/i><\/em><sup>6<\/sup>-\u7532\u57fa\u817a\u82f7\uff08<em><i>N<\/i><\/em><sup>6<\/sup>-methyladenosine\uff0cm<sup>6<\/sup>A\uff09\u4fee\u9970\uff08\u4e00\u79cd\u5728\u771f\u6838\u751f\u7269mRNA\u5e38\u89c1\u7684\u4fee\u9970\u65b9\u5f0f\uff09\u4fee\u9970\u3002\u8fdb\u4e00\u6b65\u673a\u5236\u7814\u7a76\u8868\u660e\uff0ccircSCMH1\u4fc3\u8fdb\u8111\u8840\u7ba1\u5185\u76ae\u7ec6\u80deFTO\u53d1\u751f\u6cdb\u7d20\u5316\u4fee\u9970\uff0c\u589e\u52a0FTO\u5411\u6838\u5185\u8f6c\u79fb\uff0c\u5bfc\u81f4\u8840\u7ba1\u53d1\u80b2\u76f8\u5173\u57fa\u56e0-\u8102\u8d28\u78f7\u9178\u78f7\u9178\u91763\uff08lipid phosphate phosphatase 3\uff0c<em><i>Plpp3<\/i><\/em>\uff09\u7684m<sup>6<\/sup>A\u4fee\u9970\u964d\u4f4e\uff0c\u4ece\u800c\u6291\u5236\u4e86YTHDF2\u5bf9<em><i>Plpp3<\/i><\/em>\u00a0mRNA\u7684\u964d\u89e3\uff0c\u5bfc\u81f4<em><i>Plpp3<\/i><\/em>\u00a0mRNA\u4e0e\u5176\u7f16\u7801\u86cb\u767dLPP3\u5728\u5185\u76ae\u7ec6\u80de\u4e2d\u7684\u6c34\u5e73\u589e\u52a0\uff0c\u4fc3\u8fdb\u8840\u7ba1\u4fee\u590d\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u4ece\u8840\u7ba1\u4fee\u590d\u5c42\u9762\u6269\u5c55\u4e86circSCMH1\u4fc3\u8fdb\u7f3a\u8840\u6027\u5352\u4e2d\u8111\u4fee\u590d\u7684\u673a\u5236\uff0c\u4e3a\u6cbb\u7597\u7f3a\u8840\u6027\u5352\u4e2d\u7684\u65b0\u836f\u7814\u53d1\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u548c\u65b0\u9776\u70b9\u3002\u535a\u58eb\u7814\u7a76\u751f\u674e\u658c\u548c\u595a\u6587\u4e3a\u8be5\u8bba\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u59da\u7ea2\u7ea2\u6559\u6388\u3001\u5de2\u6770\u6559\u6388\u548c\u97e9\u51b0\u526f\u6559\u6388\u4e3a\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002\u8be5\u7814\u7a76\u5f97\u5230\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u79d1\u6280\u521b\u65b0-2030\u91cd\u5927\u9879\u76ee\u548c\u6c5f\u82cf\u7701\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u7b49\u8d44\u52a9\u3002<\/p>\n<blockquote><p>\u8bba\u6587\u94fe\u63a5\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-023-36008-y\">https:\/\/www.nature.com\/articles\/s41467-023-36008-y<\/a><\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>2023\u5e741\u670830\u65e5\uff0c\u4e1c\u5357\u5927\u5b66\u533b\u5b66\u9662\u3001\u6c5f\u82cf\u7701\u91cd\u75c7\u533b\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u59da\u7ea2\u7ea2\u6559\u6388\u56e2\u961f\u5728\u56fd\u9645\u6743\u5a01\u5b66\u672f\u671f\u520a\u300aNature\u00a0 &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/wp.meddatas.com\/?p=5899\"> <span class=\"screen-reader-text\">\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u59da\u7ea2\u7ea2\u56e2\u961f\u63ed\u793a\u73af\u72b6RNA\u4fc3\u8fdb\u7f3a\u8840\u6027\u5352\u4e2d\u540e\u8840\u7ba1\u4fee\u590d\u7684\u4f5c\u7528\u53ca\u5176\u5206\u5b50\u673a\u5236<\/span> \u67e5\u770b\u5168\u6587 &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":5900,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[59],"tags":[],"_links":{"self":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts\/5899"}],"collection":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5899"}],"version-history":[{"count":2,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts\/5899\/revisions"}],"predecessor-version":[{"id":5902,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/posts\/5899\/revisions\/5902"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=\/wp\/v2\/media\/5900"}],"wp:attachment":[{"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5899"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5899"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.meddatas.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5899"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}